In vitro antioxidant, cholinesterase and tyrosinase inhibitory activities of Calophyllum symingtonianum and Calophyllum depressinervosum (Guttiferae)

Currently, there is global attention focused on finding antioxidants from natural sources, due to common synthetic antioxidants such as butylated hydroxyanisole and butylated hydroxytoluene (BHT) being reported to cause adverse effects including enzymatic and lipid alterations[1]. Antioxidants protect the body from free radicals and reactive oxygen species (ROS). ROS activity leads to skin ageing and generation of radicals in body apart from cancer. There is enough evidence in the literature to relate oxidative stress caused by ROS activity to age-related neurodegenerative diseases like Alzheimer’s disease. The use of antioxidants has been investigated in an effort to slow down the progression of such diseases[2]. Alzheimer’s disease is a progressive neurodegenerative disorder PEER REVIEW ABSTRACT